As for fixing human hearts? Perhaps manipulating thyroid hormone levels could be a start.

那人类心脏能修复吗？也许可以从控制甲状腺激水平开始。

If it's due to a primary cause, TSH will be low, an unbound thyroid hormones will be high.

如果原发性甲亢，TSH水平低，未结合的甲状腺激水平变高。

Or like you start off by explaining it, okay, hypothyroidism, okay, it's obviously where you produce less thyroid hormone.

或者你开始解释，好的，甲状腺功能减退，显然你产生的甲状腺激较少。

Because when they added extra thyroid hormone to zebrafish's tanks, their tiny hearts were no longer able to regenerate.

因为当他们向斑鱼鱼缸中加入额外的甲状腺激时，斑鱼的小心脏便不能再生了。

So, thyroid hormone for the win, right? What's not to love?

所以，甲状腺激最棒的，对吗？还有啥理由不爱它呢。

Like steroids, thyroid hormone is lipid-soluble, so it crosses the membrane of its target cell to bind inside the nucleus.

像类固醇一样，甲状腺激溶性的，所以它穿过靶细胞的膜与细胞核结合。

This results in growth of the thyroid glands and stimulates the follicular cells to produce excess thyroid hormone.

这导致甲状腺增生并刺激滤泡细胞，产生过量的甲状腺激。

If there's too much thyroid hormone, they both decrease their own hormone production, to stop stimulating the thyroid.

如果甲状腺激过多，它们都减少自身的激分泌，停止刺激甲状腺。

Another primary cause is toxic nodular goiter where one or more follicles starts generating lots of thyroid hormone.

另一个原发病因毒性结节性甲状腺肿，即一个或多个滤泡开始产生大量的甲状腺激。

Hassen called the lab. He ordered tests to check the level of thyroid hormone in the sample. It was very high.

哈森打电话给实验室，要求化验样本中甲状腺激的含量。结果显示甲状腺激含量非常高。

Also anytime the thyroid gets inflamed or damaged there can be a large release of preformed thyroid hormones.

甲状腺发炎或受损，也可能大量释放预先形成的甲状腺激。

That in turn reduces thyroid hormone levels in the blood, and slows down your metabolism again, before you get over-heated.

这反过来降低血液中的甲状腺激水平，并在你过热之前再次减慢你的新陈代谢。

A medication called methimazole, for example, decreases production of thyroid hormones.

例如，一种叫做甲巯咪唑的药物减少甲状腺激的产生。

And then if you need thyroid hormone to create DHT.

然后如果你需要甲状腺激来生成DHT。

Too much thyroid hormone causes the body to race. Too little, and it slows to a crawl. Unchecked, either state can be fatal.

甲状腺激过多导致身体处于亢奋状态。而甲状腺激过少，身体慢慢变得迟钝。如果放任不管，任何一种状态都可能致命。

Rarely, in some people - usually young, often male - too much thyroid hormone can make circulating potassium levels drop and cause weakness.

甲状腺激过量使循环钾含量下降，继而导致虚弱，这通常出现在年轻男性身上，但罕见。

Perhaps manipulating thyroid hormone levels could be a start.

或许操纵甲状腺激水平可能一个开始。

And then also lowers thyroid hormone.

并且还降低甲状腺激。

So he might not have any issues with actual thyroid hormone synthesis.

所以他可能没有任何关于实际甲状腺激合成的问题。

All of them result in too much thyroid hormone in a hyper metabolic state where cellular reactions are happening faster than normal.

其后果都产生过多的甲状腺激，形成高代谢状态，即细胞反应比正常情况发生得更快。